A graduate of Tulane University, Billy Blatty graduated Cum Laude with a degree in psychology and pre-medicine. While in college, he entered the nightlife industry in New Orleans, developing his experience as a bar-back, flyer-guy, short-order cook, security personnel, and bartender before working his way up to a managerial position. Billy Blatty's obtained his first position as a manager at Whiskey Blue in the W Hotel.
In 2000, Billy Blatty served as general manager and promoter of Club Ampersand, one of the city's newest nightclubs. The following year, he accepted full ownership and responsibility for the club, and under his leadership it became the most popular dance music venue in New Orleans, hosting performers such as Tiesto, Paul Van Dyk, Kaskade, Lil Wayne, Eric Morillo, Carl Cox, and Skrillex. Hurricane Katrina destroyed Ampersand, but Blatty rebuilt it and ran its operations until 2010. In 2010 Blatty took on a new partner and ceded operational control to Robert Brunet in order to focus on expanding his Barcadia brand and properties. Billy Blatty remained propieter until Ampersand closed in April 2014, with DJ Tiesto playing the closing event.
Now Billy Blatty continues to head several restaurants, bars, and lounges in New Orleans, Baton Rouge, Dallas, Fort Worth. These include the Asian-style Ohm Lounge and Barcadia Bars, which provide American food alongside arcades games and a 1950s atmosphere. He also produces the Jazz Fest by Night Concert Series which hosted acts Lana Del Rey, Thievery Corporation, and Pretty Lights in 2013.